KNG1 antibody

Catalog No. ABIN7115720

The Rabbit Polyclonal anti-KNG1 antibody has been validated for WB, ELISA and IF. It is suitable to detect KNG1 in samples from Human and Mouse.

Quick Overview for KNG1 antibody (ABIN7115720)

Target: KNG1 (Kininogen 1 (KNG1))

Reactivity: Human, Mouse

Host: Rabbit

Clonality: Polyclonal

Conjugate: This KNG1 antibody is un-conjugated

Application: Western Blotting (WB), ELISA, Immunofluorescence (IF)

Product Details anti-KNG1 Antibody

Purpose: KNG1 antibody

Purification: Immunogen affinity purified

Purity: ≥95 % as determined by SDS-PAGE

Immunogen: Kininogen-1

Isotype: IgG

Application Details

Application Notes: WB: 1:500-1:2000, IF: 1:50-1:200

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: PBS with 0.02 % sodium azide and 50 % glycerol pH 7.3,

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Avoid repeated freeze / thaw cycles.

Storage: -20 °C

Storage Comment: -20°C for 12 months

Expiry Date: 12 months

Target Details for KNG1

Target: KNG1 (Kininogen 1 (KNG1))

Alternative Name: KNG1

Background:

Synonyms: Kininogen-1|Alpha-2-thiol proteinase inhibitor|Fitzgerald factor|High molecular weight kininogen (HMWK)|Williams-Fitzgerald-Flaujeac factor|Kininogen-1 heavy chain|T-kinin Alternative names: Ile-Ser-Bradykinin|Bradykinin Alternative names: Kallidin I|Lysyl-bradykinin Alternative names: Kallidin II|Kininogen-1 light chain|Low molecular weight growth-promoting factor|KNG1|BDK|KNG

Background: This gene uses alternative splicing to generate two different proteins- high molecular weight kininogen (HMWK) and low molecular weight kininogen (LMWK). HMWK is essential for blood coagulation and assembly of the kallikrein-kinin system. Also, bradykinin, a peptide causing numerous physiological effects, is released from HMWK. Bradykinin also functions as an antimicrobial peptide with antibacterial and antifungal activity. In contrast to HMWK, LMWK is not involved in blood coagulation. Three transcript variants encoding different isoforms have been found for this gene.

Molecular Weight: 68 kDa

Gene ID: 3827

UniProt: P01042

Pathways: ACE Inhibitor Pathway, Glycosaminoglycan Metabolic Process